Green-lipped mussel & osteoarthritis treatment: How one of nature's most powerful anti-inflammatories works

Are you concerned about your dog's mobility and joint health? Dive into this blog to get a better understanding of the health benefits of green-lipped mussel for dogs and how it can help relieve the symptoms of osteoarthritis and reduce the use of anti-inflammatory drugs.

Mobility is the key element in keeping our canine friends healthy and happy for many years to come. Thinking back to my first dog, Skai, I was so grateful he was able to go hiking with us in the mountains even at the age of 15.

But while he seemed unstoppable, eventually stiffness and aches started to set in. Seeing your dog slow down is tough for any pet parent as mobility is everything for them — it's joy, freedom, and life itself.

Fortunately, there are natural ways to support your dog's mobility and increase their lifespan, one of them being the Perna mussel or green-lipped mussel.

In 2009, a study called An evidence-based systematic review of green-lipped mussel (Perna canaliculus)(1) confirmed that New Zealand green-lipped mussel provides a clinically significant positive treatment effect on osteoarthritis (joint inflammation). 

This study included a review of nine clinical trials, focusing on the effects of green-lipped mussels on OA pain and mobility, but also confirmed that green-lipped mussels improved gastrointestinal symptoms in OA patients taking non-steroidal anti-inflammatory medications (NSAIDs) that are widely used in human and veterinary medicine. These drugs are known to cause gastrointestinal, kidney, and liver side effects, resulting in a deeper imbalance in the body.

But that's not all, what makes green-lipped mussels so beneficial for dogs and people lies in the powerful nutrients it contains. 

What makes green-lipped mussels so unique?

A recent study conducted by a Japanese research team focused on the compounds behind the green-lipped mussel's positive effects on joint health, pain management, and mobility — the bioactive glycosaminoglycans (GAGs)(2).

Marine invertebrates such as mussels are a rich source of these highly sulfated and rare glycosaminoglycans. Perna canaliculus is one of the best sources produced on a large scale in New Zealand. 

The glycosaminoglycans from the green-lipped mussel, primarily chondroitin sulfate (CS) and heparan sulfate (HS), exhibit several notable biological effects:

1. Encouraging nerve growth: Certain chondroitin sulfate chains, especially those with a specific type of sugar pairing (GlcA-GalNAc(4,6-O-disulfate)), have been found to help in the creation of connections between nerve cells. This discovery hints at possible uses in the fields of neurology and regenerative medicine, where promoting nerve growth and repair is needed.

2. Joint health and osteoarthritis treatment: Chondroitin sulfate is commonly used for its potential benefits in joint health, particularly in the treatment of osteoarthritis. It is believed to contribute to the maintenance and repair of cartilage, the connective tissue that lines and cushions joints.

3. Anti-inflammatory properties: Both chondroitin sulfate and heparan sulfate possess anti-inflammatory properties, which are beneficial in reducing inflammation in cases of arthritis.

4. Tissue homeostasis (stability) and cell proliferation (creation and growth): GAGs play critical roles in cellular phenomena like cell proliferation, cell adhesion, differentiation, and tissue homeostasis.

Another study, this time analysing the effects of a diet enriched with green-lipped mussel in dogs with osteoarthritis(3),  observed that there was a significant increase in Omega-3 fatty acids levels in their blood after 60 days. The owners also reported improvements in their dogs' pain and activity levels after switching to this diet. 

Why I chose to add green-lipped mussel to JointButter

For those of you who have missed the latest news, JointButter, our new product and the world’s first fermented joint and mobility support supplement for dogs, will be soon added to our product line up.  

I have researched countless nutrients, herbs, and superfoods for many years in order to come up with the best possible formula that would make a clear difference for our dogs' joint health and mobility.

That's how I came across the green-lipped mussel and its powerful anti-inflammatory and joint-repair properties. The glycosaminoglycans (GAGs) from Perna mussels have a unique structure and bioactivity, making it a popular ingredient in canine and human mobility formulas.

While I've also added chondroitin sulfate and glucosamine to JointButter, the addition of a whole-food source of GAGs from Perna mussels significantly boosts the potency of the supplement and increases the spectrum of available glycosaminoglycans. 

How are green-lipped mussels raised and harvested? 

Produced exclusively in New Zealand, green-lipped mussel production involves several steps.

Seeds are first collected and planted in a hatchery. Once they hatch into larvae, they attach themselves to rocks, long ropes, and other hard surfaces.

Once attached, a transformation into juvenile and consecutively into adult mussels follows. Green-lipped mussels are ready to be harvested in 26 to 48 months.

A note on the sustainability of green-lipped mussel production

When formulating JointButter, my team and I didn’t just focus on the quality and science-backed efficacy of the ingredients we selected; we also paid close attention to their environmental sustainability. 

The regions where Perna mussels are harvested are under the stewardship of the producers in a successful collaboration with Mussel Reef Restoration Trust and Revive Our Gulf Foundation.

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• Is green-lipped mussel harvest sustainable?

Article references:

1. ”Green-lipped mussel review" by Catherine Ulbricht and team. PMID: 22435354 DOI: 10.1080/19390210802690191

Nature’s Synergy for your Dog’s Joint Health and Pain Management:  1+1 > 2

We love our dogs and want them to experience the joy of moving freely without pain. Dogs love being active which inevitably leads to injuries and also to “wear and tear” despite the best care and intentions.

As our dogs age, inflammation and arthritis are common, and so are discomfort, decline in mobility, and quality of life.

It is natural to worry about our dogs and to try to protect them from pain and inflammation. Unfortunately, these issues are often managed with NSAIDs (non-steroidal anti-inflammatory drugs), which can lead to frequent side effects such as stomach upset, gastrointestinal bleeding, damage to the liver and kidneys, and interference with the body’s own healing response.

How can we help our dogs enjoy activity without harm?

Fortunately,  the answer to finding harmless and effective mobility enhancing foods and herbs exists in nature. These nutrients can deliver a synergy of benefits for healing and prevention, especially when combined in proper amounts and prepared for maximum absorption and efficacy.

The most commonly used therapies for canine joint health only focus on rebuilding collagen by using glucosamine and chondroitin. However, managing mobility issues in dogs requires a more complete solution that addresses muscles, joints, tendons, ligaments, synovial fluid, and the inflammation and pain that is associated.

For thousands of years, traditional medicine has turned to nature for remedies and chosen spices for their many healing properties. This ancient wisdom, supported by modern science, continues to highlight the significance of spices as the powerhouses of natural healing.

Golden Spice: Turmeric’s Healing Virtues and The Science Behind Them

You may have already heard of golden paste, a home remedy commonly used by dog lovers to reduce inflammation, help arthritis and heal injuries. You may also know that the primary ingredient in golden paste is turmeric, a spice used for thousands of years in traditional medicine as an anti-inflammatory and natural pain relief remedy.

Based on the growing body of research, several studies have now confirmed that turmeric is beneficial in managing arthritis and inflammation in dogs, much like in humans.

Here are several key reasons why turmeric is a canine mobility support superstar:

• Inflammation Reduction: One of turmeric’s active components, curcumin, has been shown to possess potent anti-inflammatory properties similar to NSAIDs without the side effects, making turmeric a safer longer term alternative. ^{[5] [6] [10]}
  
  

• Cartilage Support: Turmeric can protect cartilage by inhibiting enzymes that contribute to cartilage degradation. This is very important in conditions like arthritis, where the preservation of cartilage is crucial for maintaining joint health and mobility. ^[7]

• Pain Management: Clinical studies have demonstrated that turmeric is effective in relieving pain and improving mobility in dogs with osteoarthritis. Dogs supplemented with a diet containing turmeric showed improved ability to rise from a sitting or lying position, indicating pain relief and enhanced joint function. ^[4]

• Arthritis Support: Research has demonstrated that turmeric is highly effective in improving osteoarthritis in canines. ^[12]

You can also read more about the benefits and science in my blog Turmeric for Dogs.  

One important fact to remember!

While turmeric is an amazing superfood with numerous benefits, its use comes with several challenges when given on its own. ^[8]:

• Curcumin is metabolized quickly, which reduces the concentration of bioavailable curcumin and its therapeutic effects. ^[8]

• Curcumin is swiftly eliminated from the body, further reducing its concentration to provide sustained benefits. ^[8]

• Curcumin is not easily dissolved in water, which decreases its intestinal absorption and bioavailability. ^[8]

Is there a way of getting all the healing benefits that turmeric has to offer?

The answer is YES!

Black Pepper and Turmeric - best friends and fierce allies

Are you wondering how these two spices work together?

Imagine turmeric and black pepper as two happy dogs playing in the field of health and wellness. Turmeric is like a golden retriever – vibrant, full of life, and known for its loyalty in supporting the body's well-being with its anti-inflammatory and antioxidant powers. It's eager to fetch the benefits of health and bring them back to its owner, but sometimes, it runs too fast blowing away most of the turmeric on the way, barely bringing anything to the final destination.

Black pepper, is like a border collie, focused and smart, ensuring that everything is lined up to deliver the most turmeric to the final destination.

In fact, black pepper contains piperine, a compound that “herds” or delivers turmeric to the body’s muscles, joints and inflamed tissues. Piperine also slows down the metabolism of turmeric’s active compounds, which effectively increases the concentration to achieve the greatest medicinal effect.

Together, turmeric and black pepper make perfect partners. Where turmeric might struggle on its own, black pepper is right there to help, ensuring that the turmeric’s healing effects are not in vain.

The science behind the Turmeric and Black Pepper Duo:

• Piperine, a major active component of black pepper, has been shown to increase the bioavailability of curcumin by inhibiting its metabolism, allowing higher concentrations of curcumin to remain in the body for longer periods. ^{[8] [13]}

• Combining curcumin with piperine can enhance curcumin's absorption by up to 2000% in both animals and humans with no adverse effects. ^[9]
  
  

Additional benefits of Black Pepper

• Pain and Inflammation Support: The compound piperine plays a direct role in mitigating inflammation in animals and has been tested as a natural pain reliever in studies, suggesting a promising area for future research in pain management. ^{[1] [3]}

Other “side benefits”: Research also shows black pepper's potential to promote gut health and may enhance the proliferation of beneficial gut bacteria which is important for immune function, mood regulation, and the prevention of chronic diseases. ^[2]

Preparation of Ingredients is as important as their selection

How we prepare ingredients matters as it has a direct effect on their efficacy and bio-availability.

• Using Whole Spice: We start with whole turmeric and whole black pepper and do not fractionate and damage them by trying to isolate out the curcumin or the piperine. There are hundreds of other compounds (that also work synergistically within spices and plants). When you fractionate the isolated compounds, they behave more like drugs and cause side effects. We believe in the wisdom of nature and the harmony of medicinal plants and superfoods.

• We use Fermentation, an ancient method blended with precise modern technology to enhance the bio-availability of ingredients and cultivate a wide spectrum of bioactive compounds that support digestion and nutrient absorption. This proprietary dual stage fermentation process enhances the effectiveness of turmeric and black pepper in JointButter, an advanced joint and mobility supplement for dogs.
  
  

Organic Coconut Oil  - Why 2 + 1 is more than 3

• Curcumin is fat-soluble, so adding lipids or fat-based “carriers” such as coconut oil further improves its solubility and absorption.

• However, coconut oil is more than just a carrier for the other active ingredients.

Research has shown that combining turmeric, black pepper and coconut oil is much more potent than the sum of their parts. Together they not only address inflammation and pain but also support nutritional absorption and gut health. ^[8]

You can find these super spices in our JointButter® formula, in combination with 11 other ingredients designed to support a comprehensive approach to canine mobility.

We can’t wait to hear about the transformations you will witness with your dog.

 

References

1. Bang, J. S., Oh, D. H., Choi, H. M., Sur, B. J., Lim, S. J., Kim, J. Y., ... & Kim, K. S. (2009). Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Research & Therapy, 11(2), R49.

2. Butt, M. S., Pasha, I., Sultan, M. T., Randhawa, M. A., Saeed, F., & Ahmed, W. (2013). Black pepper and health claims: a comprehensive treatise. Critical Reviews in Food Science and Nutrition, 53(9), 875-886.

3. Tasleem, F., Azhar, I., Ali, S. N., Perveen, S., & Mahmood, Z. A. (2014). Analgesic and anti-inflammatory activities of Piper nigrum L. Asian Pacific Journal of Tropical Medicine, 7(Suppl 1), S461-S468.

4. Comblain, F., Barthélémy, N., Lefèbvre, M., Schwartz, C., Lesponne, I., Serisier, S., ... & Henrotin, Y. (2017). A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis. BMC Veterinary Research, 13(1), 395.

5. Kuptniratsaikul, V., Dajpratham, P., Taechaarpornkul, W., Buntragulpoontawee, M., Lukkanapichonchut, P., Chootip, C., ... & Laongpech, S. (2014). Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clinical Interventions in Aging, 9, 451-458.

6. Shahrajabian, M. H., & Sun, W. (2023). The Golden Spice for Life: Turmeric with the Pharmacological Benefits of Curcuminoids Components, including Curcumin, Bisdemethoxycurcumin, and Demethoxycurcumin. Current Organic Synthesis.

7. Mathy-Hartert, M., Jacquemond-Collet, I., Priem, F., Sanchez, C., Lambert, C., & Henrotin, Y. (2009). Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflammation Research, 58(12), 899-908.

8. Prasad, S., Tyagi, A. K., & Aggarwal, B. B. (2014). Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice. Cancer Research and Treatment, 46(1), 2–18.

9. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. S. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353-356.

10. Peng, Y., Ao, M., Dong, B., Jiang, Y., Yu, L., Chen, Z., ... & Xu, R. (2021). Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures. Drug Design, Development and Therapy, 15, 4503–4525.

11. Corbee, R. J. (2022). The efficacy of a nutritional supplement containing green‐lipped mussel, curcumin and blackcurrant leaf extract in dogs and cats with osteoarthritis. Veterinary Medicine and Science, 8(3), 1025–1035.

12. Sheahan, S. (2022). Efficacy of turmeric for treatment of osteoarthritis: A systematic review and meta-analysis of experimental animal model studies. American Journal of Traditional Chinese Veterinary Medicine, 17(1), 3-12.

13. Pratti, V. L., Thomas, M., Bhoite, R., & Satyavrat, V. (2024). Investigating Bioavailability of Curcumin and Piperine Combination in Comparison to Turmeric Rhizomes. Journal of Experimental Pharmacology, 16, doi.org/10.2147/JEP.S427818.

 

"Your dog has arthritis." It's a common phrase heard among pet parents and something every one of us tries hard to avoid.

But what exactly can we do? Are there breeds that are more prone? Do we supplement? What age do we start? These are the most common mobility-related questions on the minds of pet owners today, and I am here to help answer them.

Glucosamine and chondroitin have long been staples for dogs' joint health, especially for senior dogs suffering from joint pain and arthritis. They are not just popular among pet parents—they are also commonly recommended by canine mobility experts and veterinarians.

What is glucosamine?

Glucosamine is a substance naturally found in the body that helps in the formation and repair of damaged cartilage. It acts as an anti-inflammatory and is used to stimulate cartilage production to keep joints flexible. This helps in reducing pain in dogs with osteoarthritis and other joint-related issues.^[1][3]

What is chondroitin?

Chondroitin is also found naturally in the body's cartilage, which provides the building blocks for the body to build new cartilage. It keeps cartilage healthy by absorbing fluid into the connective tissue, keeping it spongy, resilient, and healthy. Chondroitin also blocks the enzymes that break down cartilage, helping slow down the degeneration seen with osteoarthritis.^[1][3][6]

Is one better than the other?

Glucosamine and chondroitin are often combined in joint supplements for dogs as they work best in synergy, complementing one another in maintaining and repairing cartilage. From improving stiffness to mobility to reducing pain, they are two important ingredients to include in your dog's diet to support their overall joint health and help offer pain relief.^[3][5]

How does my dog benefit from glucosamine and chondroitin? 

Glucosamine and chondroitin are particularly beneficial for dogs suffering from joint issues, including hip or elbow dysplasia and arthritis, and those recovering from joint-related surgeries, like cranial cruciate ligament (CCL) repair. Glucosamine and chondroitin supplements provide pain relief and improve canine mobility, but they also contribute to delaying age-related joint degeneration while offering anti-inflammatory properties.^[2][3]

Do young dogs require joint supplements?

Research has shown that glucosamine and chondroitin are far more effective at maintaining and repairing joint health when they are introduced to a dog's diet earlier in life, when the damage is potentially too severe. Supplementation is especially important in active, performance, or working dogs. Maintaining your dog's joint health early on will help them live a more active and pain-free life for longer, which is what we all strive for.^[4]

What is the correct dosage?

The right dosage depends on the dog's weight, age, and goals and objectives. For example, it can be used as joint support to treat injuries or address degenerative joint disease and osteoarthritis. Typical guidelines suggest a range of 250 mg—1500 mg. I generally suggest adhering to the product instructions printed on the product label for accurate dosage.

Glucosamine and chondroitin are generally considered safe for long-term use with no side effects. 

The importance of an integrative and holistic approach

While these supplements are essential for joint health, the optimal approach is to take advantage of their synergy with other mobility-health supplements and superfoods.

A species-appropriate diet with essential nutrients, omega-3 oils, and probiotics are crucial for your dog's overall health and well-being. Keeping your dog in shape with frequent and age-appropriate exercise is also a key aspect in preventing the early onset of canine arthritis. 

Choosing the best glucosamine and chondroitin supplement:

Due to the vast array of dog joint supplements available, you need to look beyond the traditional glucosamine and chondroitin, and combine them with other ingredients of the mobility formula.

Here is a list of joint, mobility and injury-centric herbs and superfoods and the research behind them:

• Turmeric and Black Pepper
• Boswellia 
• Barley Grass
• Quercetin
• Rutin
• MSM
• Ginger root
• Stinging Nettle leaf
• Vitamin C
• Coconut oil
• Olive Oil

Also, the quality, potency, and purity of ingredients vary significantly, making it crucial for dog guardians to choose wisely for their dogs.

Beware of low-cost supplements, as they may contain harmful heavy metals and other toxins that can diminish the health benefits of these supplements. 

Focus on a formula that contains whole foods, ideally fermented ingredients that offer the most significant benefits, such as perna mussel, turmeric, Boswellia, and others. 

The bottom line:

A high-quality, fermented mobility supplement provides a great foundation to support joint and ligament development in young dogs, but it also helps to alleviate pain and inflammation in case of injuries and osteoarthritis.

Additional tips to keep your dog's joints happy:

• Weight management: overweight dogs are more likely to develop joint issues

• Nutrition: a natural, ideally home raw or cooked diet rich in omega-3 fatty acid supplements are also essential for excellent joint health
  
  
• Hydration: keeping the body hydrated helps maintain joint lubrication and reduce inflammation
  
  
• Regular exercise: regular and age-appropriate physical activity can help maintain joint health significantly. Let young dogs and puppies run and play, but only expose them to strenuous activities and hikes once they gradually develop strength. Strengthening exercises can play a vital role in supporting your dog's joints 
  
  
• Routine vet and chiropractic or physical therapy checkups are also a part of the preventive joint and mobility protocol 
  
  

References

1. McCarthy, G., O’Donovan, J., Jones, B., McAllister, H., Seed, M., & Mooney, C. (2007). Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. The Veterinary Journal, 174(1), 54-61.
   
   
2. Jerosch, J. (2011). Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. International Journal of Rheumatology, 2011, Article 969012.
   
   
3. Martel-Pelletier, J., Roubille, C., Abram, F., Hochberg, M. C., Dorais, M., Delorme, P., Raynauld, J.-P., & Pelletier, J.-P. (2015). First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort. Annals of the Rheumatic Diseases, 74(3), 547-556.
   
   
4. Neil, K. M., Caron, J. P., & Orth, M. W. (2005). The role of glucosamine and chondroitin sulfate in treatment and prevention of osteoarthritis in animals. Journal of the American Veterinary Medical Association, 226(7), 1079-1088.
   
   
5. Dechant, J. E., Baxter, G. M., Frisbie, D. D., Trotter, G. W., & McIlwraith, C. W. (2005). Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explant metabolism. Equine Veterinary Journal, 37(3), 227-231.
   
   
6. Chan, P.-S., Caron, J. P., & Orth, M. W. (2005). Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1–challenged bovine articular cartilage explants. American Journal of Veterinary Research, 66(11), 1870.

 

Uncovering the health benefits of Boswellia as part of holistic joint care in dogs

You’ll often see Boswellia on the ingredient list of canine mobility supplements, yet its healing properties, which go beyond joint health support and natural pain relief, have been used in traditional Ayurvedic medicine for thousands of years.

Boswellia serrata originates from regions such as the Arabian Peninsula and parts of India.

In fact, it is a resin obtained through the process of bark tapping, which allows the collection of sap. This sap, initially a sticky, milky substance, undergoes a natural drying process on the tree, solidifying into the characteristic resin crystals.

These crystals, varying in hue from pale yellow to deep amber, are not only valued for their aromatic qualities. Boswellia has been used in medicine for its anti-inflammatory and analgesic properties. One of the reasons for that is that this ancient resin is considered a safer alternative to conventional drugs.

Compared to NSAIDs or steroids that create deep imbalances and contribute to long-term digestive, renal and liver issues, Boswellia contains unique bioactive compounds that work in harmony with the body's natural anti-inflammatory processes.

So, what is the best way for your dog to benefit from Boswellia’s healing properties? Are there any side effects? How about choosing the right mobility supplement for your canine friend?

Before I get into all that, let’s start with how this ancient natural remedy works in dogs.

Understanding Boswellia: Composition and properties

Boswellia contains Boswellic acids, potent active chemical components that help treat inflammation at the cellular level. Boswellic acids have been extensively studied for a number of health conditions^[1] due to their anti-inflammatory, antitumor, immunomodulatory, and antioxidant properties.

Research has shown that one of these compounds, namely acetyl-11-keto-β-boswellic acid (AKBA), targets and inhibits 5-lipoxygenase (5-LOX)^[2], an enzyme responsible for inflammation.

These findings support the use of Boswellia as a natural remedy for chronic inflammation in dogs and other health conditions associated with it, including arthritis, diabetes, liver disease, dementia, and cancer.

Boswellia health benefits in dogs

Narrowing the benefits of Boswellia to merely joint pain control and inflammation relief would undersell its immense potential. The benefits of this plant extract extend to several other health areas that make it a worthy addition to your dog's diet.

• Promote healthy joints and relieve arthritis symptoms

Several veterinary centers in Switzerland conducted a study involving 29 dogs with degenerative joint and spinal conditions^[3] in which Boswellia serrata extract was administered for six weeks.

The dogs showed significant improvements in the severity of symptoms such as lameness, pain, and stiffness, thus establishing Boswellia as an effective natural treatment option for dog arthritis.

That’s excellent news, considering the prevalence of inflammatory conditions and joint-related issues in dogs. Research shows that up to 80% of dogs over eight years old will exhibit signs of arthritis, while 20% will develop symptoms as early as the age of one^[4].

• Maintain optimal brain health and reduce oxidative damage

A study reviewing the anti-inflammatory and neuroprotective properties of AKBA, one of the most powerful Boswellic acids, highlights its potential in treating neurological diseases^[5] by promoting nerve repair, lowering neuroinflammation, protecting against oxidative damage, and combating gliomas (cancerous brain tumours).

Moreover, Boswellia supplementation has been shown to be effective in treating age-associated memory decline. Research conducted on aged rats indicated that the resin extract improved their overall memory and learning abilities^[6] by altering the structure of their hippocampus (memory center).

• Help improve liver function in inflammatory disorders

A clinical study on rats with non-alcoholic fatty liver disease (NAFLD) found that AKBA helps reduce liver inflammation, improve hepatic steatosis and regulate fat metabolism^[7], critical factors in preventing and managing this condition.

Boswellia’s hepatoprotective and antioxidant properties have also been found to help alleviate liver fibrosis^[8] (liver scarring due to chronic injury or disease) by improving liver function markers and boosting the organ’s antioxidant levels.

• Support the gut microbiome and relieve IBD symptoms 

Boswellia can help promote optimal gastrointestinal health, soothing the symptoms of common digestive disorders, including gastritis and inflammatory bowel disease (IBD). Boswellic acids such as AKBA have been proven to aid in the restoration of intestinal barrier integrity^[9], which becomes disrupted in patients with IBD.

Boswellia supplementation can also impact the gut microbiome composition^[10] and improve overall health. A clinical study on healthy mice noticed an increase in Akkermansia muciniphila after AKBA treatment. Akkermansia muciniphila is a bacteria strain that is crucial for strengthening the gut barrier, regulating metabolism, and lowering inflammation.

• Help regulate immune system response

Researchers found that certain Boswellic acids can reduce the growth and activation of T cells, the immune cells that help protect the body against pathogens, without harming the cells. These findings suggest the extract’s potential for treating autoimmune and inflammatory diseases and limiting overactive immune responses^[11].

Why Fermentation and combining Boswellia with other natural remedies: How to choose the right joint support supplement

Joint wear and tear is a natural part of life for dogs, regardless of their age or breed. Yet, this can often lead to injuries and joint conditions and cause chronic inflammation, pain, and stiffness, thus decreasing your dog's quality of life.

That’s why choosing the best mobility and joint support supplement for your dog can make all the difference not only for their health and mobility but also for their lifespan.

Look for Boswellia-containing supplements that are fermented to enhance the formula

When choosing a canine supplement, you might also want to consider sustainable sourcing, third-party purity testing, and eco-friendly packaging. These elements will ensure your dog gets a high-quality product that benefits their health and protects the environment at the same time.

 

Meet the latest innovation in natural canine joint care: What is JointButter®?

JointButter is our advanced joint, mobility, and injury supplement for dogs and the newest addition to our natural dog health product line (soon in the Healing Store!).

JointButter’s formula is based on a proprietary fermentation process and contains a unique blend of active compounds with joint-supporting properties, such as Boswellia, that help ensure pain-free movement in dogs of all ages.

Unlike conventional anti-inflammatory medications, JointButter® works with the body rather than causing further imbalance and harmful adverse reactions.

Don't miss out on our early-bird discounts and more when JointButter launches!
 

  

Boswellia for dogs FAQs

•  What does Boswellia do for dogs?

Multiple research studies have confirmed that Boswellia is an effective natural remedy for managing pain and inflammation in adult and older dogs diagnosed with degenerative joint conditions. The body metabolizes Boswellia into active compounds known as Boswellic acids, which have potent anti-inflammatory, immune-modulating, and antioxidant properties.

• Are there any side effects of Boswellia?

As we use fermented Boswellia in synergy with other ingredients, we have not observed any side effects. However, in rare instances, a sensitive dog may experience gastrointestinal symptoms to any supplement. If your dog shows such symptoms, stop the supplement and consider consulting your veterinarian.

• Can dogs take Turmeric and Boswellia?

Yes, they can, and they should! Both Turmeric and Boswellia are known for their anti-inflammatory and analgesic effects and can help manage arthritis symptoms in dogs. Their synergistic effect in dog health supplements can offer enhanced health benefits.

References

1. Roy, N. K., Parama, D., Banik, K., Bordoloi, D., Devi, A. K., Thakur, K. K., ... Kunnumakkara, A. B. (2019). An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases. International Journal of Molecular Sciences, 20(17), 4101. https://doi.org/10.3390/ijms20174101

2. Sailer, E. R., Subramanian, L. R., Rall, B., Hoernlein, R. F., Ammon, H. P., & Safayhi, H. (1996). Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity. British Journal of Pharmacology, 117(4), 615–618. https://doi.org/10.1111/j.1476-5381.1996.tb15235.x

3. Reichling, J., Schmökel, H., Fitzi, J., Bucher, S., & Saller, R. (2004). Dietary support with Boswellia resin in canine inflammatory joint and spinal disease. Schweizer Archiv für Tierheilkunde, 146(2), 71–79. https://doi.org/10.1024/0036-7281.146.2.71

4. Anderson, K. L., Zulch, H., O'Neill, D. G., Meeson, R. L., & Collins, L. M. (2020). Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review. Frontiers in Veterinary Science, 7, 220. https://doi.org/10.3389/fvets.2020.00220

5. Gong, Y., Jiang, X., Yang, S., et al. (2022). The Biological Activity of 3-O-Acetyl-11-keto-β-Boswellic Acid in Nervous System Diseases. NeuroMolecular Medicine, 24, 374–384.

6. Hosseini-Sharifabad, M., Kamali-Ardakani, R., & Hosseini-Sharifabad, A. (2016). Beneficial effect of Boswellia serrata gum resin on spatial learning and the dendritic tree of dentate gyrus granule cells in aged rats. Avicenna Journal of Phytomedicine, 6(2), 189–197.

7. Kachouei, R. A., Doagoo, A., Jalilzadeh, M., Khatami, S. H., Rajaei, S., Jahan-Abad, A. J., ... Karima, S. (2023). Acetyl-11-Keto-Beta-Boswellic Acid Has Therapeutic Benefits for NAFLD Rat Models That Were Given a High Fructose Diet by Ameliorating Hepatic Inflammation and Lipid Metabolism. Inflammation, 46(5), 1966–1980. https://doi.org/10.1007/s10753-023-01853-y

8. Ahmed, H. H., El-Alfy, N. Z., Mahmoud, M. F., & Yahya, S. M. M. (2015). Boswellia serrata oleo-gum resin: A natural remedy for retrogradation of liver fibrosis in rats. Der Pharmacia Lettre, 7, 134–144.

9. Catanzaro, D., Rancan, S., Orso, G., Dall'Acqua, S., Brun, P., Giron, M. C., ... Montopoli, M. (2015). Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage. PLoS ONE, 10(5), e0125375. https://doi.org/10.1371/journal.pone.0125375

10. Suther, C., Daddi, L., Bokoliya, S., Panier, H., Liu, Z., Lin, Q., ... Zhou, Y. (2022). Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models. Nutrients, 14(4), 814. https://doi.org/10.3390/nu14040814

11. Abdo Meyiah, M., Shawkat, M. Y., Rehman, N. U., Al-Harrasi, A., & Elkord, E. (2023, September). Effect of Boswellic acids on T cell proliferation and activation. International Immunopharmacology, 122.

 

Explore the powerful benefits of fermented ginger in dogs and people

As dog guardians, our main priority is the health and happiness of our canine family members which greatly depends on their mobility and being pain free.

As we become more aware of the conventional drug side-effects, an increasing number of dog lovers are on the lookout for safe, natural ways to keep their dogs injury, arthritis and inflammation free, and the same applies to recovery from injuries and surgery. Surprisingly, fermented ginger has been gaining attention, especially in the area of digestive health and mobility.

Ginger is a superfood that offers a natural way to ease discomfort, enhance mobility, and support joint health but it also promotes the overall health of the digestive tract, immune system, and skin.  However, not all ginger supplements are created equal. The method of preparation of ginger matters, and taking ginger through the process of fermentation significantly increases its bioavailability and potency. 

This post is about the scientific basis of how fermented ginger can help your dog.

The Tradition and Science Behind Ginger

Ginger has been used for thousands of years to treat a variety of ailments. From soothing an upset stomach to reducing inflammation, this powerful root has made its way into modern cuisine but also into medicine cabinets.

Ginger contains more than 100 active compounds, but two, in particular, gingerols and shogaols, have caught the attention of scientists. These compounds have anti-inflammatory and antioxidant properties, making them beneficial for humans but also dogs.

Active Ingredients and Research Behind Ginger

The study titled "Effect of Ginger on Inflammatory Diseases ^[1] published in "Molecules" in November 2022 reviews the therapeutic potential of ginger against common inflammatory diseases such as ulcerative colitis, Crohn's disease, rheumatoid arthritis, psoriasis, and lupus erythematosus.

The bioactive compounds in ginger, particularly 6-shoagol, zingerone, and 8-shoagol, have been identified for their antioxidant and anti-inflammatory properties, which can significantly improve the quality of life for patients suffering from these conditions.

How Does Ginger Work?

Ginger's effectiveness against inflammatory diseases is attributed to its ability to modulate immune responses and reduce inflammation through various mechanisms.

For example, in rheumatoid arthritis, ginger compounds have shown promising results in reducing symptoms by inhibiting inflammatory cytokines and pathways.

Similarly, in the context of inflammatory bowel disease, ginger has demonstrated the ability to modulate gut microbiota and inflammatory responses, contributing to symptom relief.

For systemic lupus erythematosus, 6-gingerol has shown a protective effect by attenuating neutrophil extracellular trap release. In cases of psoriasis, ginger's ability to decrease NF-κB suggests its potential as an alternative treatment approach.

Additionally, ginger may offer protective effects against cancer and mitigate the side effects of chemotherapy, such as nausea.

Another study from the Journal of Basic Medical Sciences,^[2] published in 2022, explores the potential of ginger in managing metabolic syndrome—a cluster of conditions that include high blood sugar, cholesterol, obesity, and hypertension.

This study suggests that  ginger gingerol and shogaol in vascular and heart disease, helps weight loss, reduces blood sugar levels and improving cellular energy metabolism.

A randomized, placebo-controlled, and double-blind clinical trial ^[3] published in *Natural Product Research* in June 2023, researchers explored the long-term effects of a dietary supplement containing Cannabis sativa oil, Boswellia serrata and Zingiber officinale (ginger) on dogs with osteoarthritis (OA) post-physiotherapy treatments. 

The study evaluates the supplement's efficacy in reducing inflammation, oxidative stress, and chronic pain in dogs after ceasing three months of prior physiotherapy.

Over three months, the study observed notable improvements in the treatment group compared to the placebo group, including increased levels of glutathione (GSH) and decreased levels of C-reactive protein (CRP) in the blood. These findings suggest the supplement's potential in alleviating symptoms associated with osteoarthritis in dogs.

The Role of Fermentation Supplement Quality

When it comes to choosing supplements for our dogs, especially something as powerful as ginger, understanding the process behind their creation is crucial. One method that stands out both for its ancient roots and modern scientific validation is fermentation as a key player in enhancing the potency and bioavailability of supplements, including ginger.

Why Fermentation Matters

Fermentation is a natural process that transforms the basic constituents of food and herbs, increasing their nutritional value and making them more digestible. When applied to ginger containing supplements, fermentation does more than just break down the root into a more palatable form. It amplifies ginger's beneficial properties, making the active compounds more accessible for your dog's body to absorb.

Enhanced Bioavailability

The main advantage of fermented ginger supplements lies in their bioavailability. This means that the nutrients in the supplement are more readily absorbed and utilized by your dog's body, ensuring they receive the full spectrum of benefits. Fermented ginger is easier on the stomach and can be more effective in supporting joint health, reducing inflammation, and aiding in muscle recovery.

Choosing the Right Supplement

Not all ginger containing supplements are created equal. When selecting a ginger supplement for yourself or your dog, opting for a fermented product ensures maximum health benefits.

Here are two examples of fermented mobility and also gut health supplements:

GutSense - pre, probiotic and digestive support

JointButter - advanced joint, arthritis, injury and mobility support

Incorporating Fermented Ginger into Your Dog's Diet

Integrating fermented supplements containing fermented ginger into your dog's diet can be a game-changer, especially for those dealing with arthritis, mobility issues, digestive imbalances,

The Bigger Picture

Incorporating fermented ginger into your dog's diet is just one aspect of achieving better mobility. Proper nutrition, regular exercise, and routine veterinary care are all crucial components of keeping your dog healthy and happy. You can significantly improve their quality of life, helping them enjoy many happy and active years by your side.

 References

1. Ballester, P., Cerdá, B., Arcusa, R., Marhuenda, J., Yamedjeu, K., & Zafrilla, P. (2022). Effect of Ginger on Inflammatory Diseases. Molecules, 27(21), 7223.

2. Salaramoli, S., Mehri, S., Yarmohammadi, F., Hashemy, S. I., & Hosseinzadeh, H. (2022). The effects of ginger and its constituents in the prevention of metabolic syndrome: A review. Iranian Journal of Basic Medical Sciences, 25(6), 664–674.

3. Gabriele, V., Bisanzio, D., Riva, A., Meineri, G., Adami, R., & Martello, E. (2023). Long-term effects of a diet supplement containing Cannabis sativa oil and Boswellia serrata in dogs with osteoarthritis following physiotherapy treatments: a randomised, placebo-controlled and double-blind clinical trial. Natural Product Research, 37(11), 1782-1786. DOI: 10.1080/14786419.2022.2119967.

 

The undervalued superfood that deserves your attention

If you have spent a lot of time outdoors, you may be familiar with a prickly plant that is guaranteed to leave a lasting impression. Even with the slightest brush against the skin, a painful sting and welt will form thanks to the tiny, hollow needles that line the stem and leaves of stinging nettle. 

Going by the Latin name Urtica dioica, stinging nettle, nettle, or burn nettle can be found growing in almost every country in gardens, fields, and banks of streams. It is one of the most undervalued medicinal plants on this earth. 

Rich in vitamins (such as A, C, and K), minerals (including iron, boron, magnesium, and calcium), amino acids, polyphenols, and fatty acids, stinging nettle's anti-inflammatory, antioxidant, and analgesic properties, make it an excellent supplement for joints, allergies, digestive disorders, and general health.^[1] 

For centuries, humans have been benefiting from stinging nettle, and recent scientific studies have contributed to its rising popularity. 

Is stinging nettle safe or toxic for dogs?

In its natural form, stinging nettle may seriously irritate the skin, the mouth and digestive system (ouch!). 

Fortunately, once dried, the formic acid and specific proteins that cause the stinging reaction are neutralized, providing powerful healing benefits for dogs and humans. This is why feeding your dog stinging nettle in either a dry powder or tincture form is crucial.

A curious fact: Nettle Eating Competitions occur in the UK, where participants eat as many stinging nettle leaves as possible within a set time. This might sound like a form of torture to some, but it's a celebrated event with historical roots and a festive atmosphere.

Benefits of stinging nettle for dogs

1. Allergy relief: Stinging nettle, with its antihistamine and anti-inflammatory properties, can mitigate allergic reactions in dogs. This is particularly beneficial when dogs suffer from itchy skin and other allergic symptoms during allergy seasons.^[2][3]
   
   
2. Cancer support: With its strong antihistamine properties, stinging nettle may help reduce the growth of certain cancers, like mast-cell tumors (MCT), by blocking histamine H1 receptors and preventing degranulation.^[5]
    
3. Skin and coat health: The plant's rich nutrient profile supports skin health, promoting a shiny coat and reducing dandruff and itchiness.^[1][2]
   
   
4. Joint support: Its anti-inflammatory effects help dogs with arthritis, osteoporosis, and other joint issues, reducing pain and improving mobility.^[2][5][6]
   
   
5. Bone health: Rich in vitamin K, stinging nettle contributes to bone health by enhancing osteoblastic activity, which is essential for bone formation and strengthening.^[1]

Curious fact: Stinging nettle has been used as a coagulant in cheesemaking. The ability of nettle juice to curdle milk has been exploited in traditional cheesemaking practices, providing a natural alternative to animal rennet. This method also imparts a subtle flavor and increases the cheese's nutritional value.

6. Urinary health: Stinging nettle acts as a diuretic, supporting kidney function and urinary health. It can help flush out toxins and alleviate symptoms of urinary tract infections.^[5]
   
   
7. Brain health: Research has shown that stinging nettle has positive and promising effects on the treatment of Parkinson's disease. It supports brain cell health, reduces oxidative stress, and slows cognitive decline.^[4]
   
   
8. Digestive aid: Nettle can improve digestive health by supporting the gut flora and aiding in nutrient absorption.^[1]

Curious fact: Stinging nettles have been used as a survival food during times of scarcity. They can be boiled to remove the sting and eaten as a leafy vegetable. Additionally, nettle tea is nutritious and has been used historically as a cleansing spring tonic to rid the body of winter sluggishness.

The power of fermentation

Fermenting stinging nettle enhances its benefits. Breaking down the plant's cellular structure makes its nutrients more accessible and digestible (bioavailable), which also increases its efficacy. Fermentation also introduces beneficial bacteria, contributing to a healthy gut microbiome in dogs.

How to use fermented stinging nettle for dogs

Fermented stinging nettle is an excellent addition to your dog's diet to help support arthritis and joint health, immune systems, allergies or skin disorders, and bone health and healing. It should be given in powdered or liquid form and makes an excellent joint supplement. 

Conclusion

Stinging nettle, particularly when fermented, offers numerous health benefits for dogs, ranging from allergy relief and improved skin condition to joint support and digestive health. However, like any supplement, if your dog has any pre-existing conditions, it is essential to contact your veterinarian or work with a canine herbalist to ensure best practice. With its natural healing properties, stinging nettle is a valuable addition to your dog's wellness regimen.

References

1. Bhusal, K. K., Magar, S. K., Thapa, R., Lamsal, A., Bhandari, S., Maharjan, R., & Shrestha, J. (2022). Nutritional and pharmacological importance of stinging nettle, Urtica dioica L.: A review. Heliyon, 8(6), e09717. doi: 10.1016/j.heliyon.2022.e09717

2. Wynn, S. G., & Fougère, B. J. (2007). Veterinary Herbal Medicine: A Systems-Based Approach. Veterinary Herbal Medicine, 291–409. doi: 10.1016/B978-0-323-02998-8.50024-X

3. Roschek Jr, B., Fink, R. C., McMichael, M., & Alberte, R. S. (2009). Nettle extract, Urtica dioica, affects key receptors and enzymes associated with allergic rhinitis. Phytother Res, 23(7), 920-926. doi: 10.1002/ptr.2763

4. Albadawi, E., El-Tokhy, A., Albadrani, M., Adel, M., El-Gamal, R., Zaarina, W., El-Agawy, M. S. E., & Elsayed, H. R. H. (2024). The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats. Cell, 87, 102328.

5. Kregiel, D., Pawlikowska, E., & Antolak, H. (2018). Urtica spp.: Ordinary Plants with Extraordinary Properties. Molecules, 23(7). doi: 10.3390/molecules23071664

6. Randall, C., Randall, H., Dobbs, F., Hutton, C., & Sanders, H. (2000). Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. Journal of the Royal Society of Medicine, 93(6), 305-309. doi: 10.1177/014107680009300607

 

In recent years, barley grass has been growing in popularity as a superfood for humans; however, dogs have consumed grass instinctively for thousands of years.

The primary reason is that barley grass has been shown to have a wide range of health-promoting properties, including immune support, digestive health, detox, and reduction in joint pain and inflammation.

Barley grass is abundant in chlorophyll, a molecule that is very close to hemoglobin in the blood, but also contains superoxide dismutase, lutonarin, saponarin, vitamins, minerals, and eight essential amino acids ^{[1] [2]}, which provide a wide range of health benefits in dogs and people. The complete essential amino acid profile also makes barley grass one of the most known nutrient-rich foods.

Barley Grass: History and Ancient Tradition

Barley grass has been cultivated for thousands of years, with ancient civilizations like the Sumerians, Egyptians, Greeks, and Romans recognizing its nutritional and medicinal properties. It was used for food, medicine, rituals, and valued for its high nutrient content. Ancient healers like Hippocrates and Pliny the Elder used barley grass to treat illnesses and digestive disorders.

A Closer Look at the Nutritional Benefits of Barley Grass for dogs

• Vitamins 

Barley grass is rich in vitamins such as vitamin A, vitamin C, and vitamin K. These vitamins play essential roles in maintaining a dog's overall health. For example, vitamin A is important for vision, immune function, and skin health, while vitamin C acts as an antioxidant and supports immune function.

• Minerals

Barley grass contains important minerals such as calcium, magnesium, and iron. These minerals are essential for, but not limited to, bone health, muscle function, and blood oxygen transport.

In fact, barley grass contains 11 times the calcium and 30 times the vitamin B1 found in cow's milk, seven times the vitamin C in oranges, six times the carotene content in spinach, and four times the vitamin B1 content of wheat flour.

• Antioxidant Allies: Barley Grass and Canine Health

Barley grass contains antioxidants such as flavonoids and chlorophyll. Antioxidants help neutralize harmful free radicals in the body which can reduce oxidative stress and inflammation. Saponarin in barley grass possesses strong antioxidant activities, which can prevent diseases caused by oxidative damage, such as various cancers, inflammations, and cardiovascular diseases. ^[3]

• Barley Grass and Canine Digestive Health

Barley grass is an excellent source of dietary fiber, which plays a crucial role in digestive health. It promotes regular bowel movements, prevents constipation, and supports the growth of beneficial gut bacteria and microbiome health.  It also plays an important role in blood sugar regulation and reducing the risk of obesity in dogs.

Barley grass can be also helpful in calming down gastrointestinal inflammation in colitis, pancreatitis, and improving the function of the intestinal lining ^{[4] [5] [6]}.

The Role of Barley Grass in Your Dog's Mobility

The wide variety of bioactive compounds in barley grass includes saponarin, a crucial functional component with natural anti-inflammatory properties ^[7].

A study has also confirmed that extracts from barley grass have demonstrated notable efficacy in the treatment of osteoarthritis and rheumatoid arthritis.

Our fermented joint and mobility product JointButter contains this beneficial plant. 

To learn more, click the link below.

FAQ for Barley Grass for Dogs:

• How much barley grass is safe for dogs?

Similarly to other super greens, feeding 1- 3 teaspoons per day based on the size of your dog should be fine.  Large amounts of barley grass may potentially cause digestive problems such as vomiting, nausea, and diarrhea. In such cases, reduce the amount and re-evaluate the dose.

• Is barley grass suitable for dogs of all ages?

Yes, barley grass is beneficial for all life stages, including puppies, middle aged and senior dogs and it is especially beneficial in dogs that tend to overheat easily and seek cooler temperatures.

• Can barley grass support detoxification?

Barley grass has excellent detox properties and helps to support the liver and eliminates toxins, and heavy metals.

• Can barley grass offer relief for dogs experiencing allergies?

Allergies and the immune system are closely intertwined with the gut, immune system health and toxin buildup. This is why barley grass can benefit dogs suffering from allergies.

References

1. Lahouar, L., El-Bok, S., & Achour, L. (2015). Therapeutic potential of young green barley leaves in prevention and treatment of chronic diseases: an overview. The American Journal of Chinese Medicine, 43(7), 1311–1329. https://doi.org/10.1142/S0192415X15500743

2. Acar, O., Turkan, I., & Ozdemir, F. (2001). Superoxide dismutase and peroxidase activities in drought sensitive and resistant barley (Hordeum vulgare L.) varieties. Acta Physiologiae Plantarum, 23(3), 351–356. https://doi.org/10.1007/s11738-001-0043-8

3. Kamiyama, M., & Shibamoto, T. (2012). Flavonoids with Potent Antioxidant Activity Found in Young Green Barley Leaves. Journal of Agricultural and Food Chemistry, 60(25), 6260–6267. https://doi.org/10.1021/jf301700j

4. Ikeguchi, M., Tsubata, M., Takano, A., et al. (2014). Effects of young barley leaf powder on gastrointestinal functions in rats and its efficacy-related physicochemical properties. Evidence-based Complementary and Alternative Medicine, 2014, 7. https://doi.org/10.1155/2014/974840.974840

5. Ohtake, H., Yuasa, H., Komura, C., Miyauchi, T., Hagiwara, Y., & Kubota, K. (Year). Studies on the constituents of green juice from young barley leaves: antiulcer activity of fractions from barley juice.

6. Ferrone, M., Raimondo, M., & Scolapio, J. S. (2007). Pancreatic enzyme pharmacotherapy. Pharmacotherapy, 27(6), 910–920. https://doi.org/10.1592/phco.27.6.910

7. Seo, K. H., Park, M. J., Ra, J. E., et al. (2014). Saponarin from barley sprouts inhibits NF-κB and MAPK on LPS-induced RAW 264.7 cells. Food and Function, 5(11), 3005–3013.

 

 

Quercetin, a naturally occurring flavonoid found in many fruits, vegetables, leaves, and grains, has attracted significant attention for its potential health benefits and therapeutic ability in both animal models and humans.

Dietary Sources and Bioavailability

Quercetin is in foods like berries and apples which are particularly rich sources.

However, its bioavailability is influenced by the form in which it's consumed, this is why we have chosen fermented quercetin in JointButter®.  The fermentation process makes the active ingredients more potent.

How does quercetin work and is it safe for dogs?

A study by Moon, Wang, DiCenzo, & Morris (2008).^[1] and Graefe, Derendorf, & Veit (1999).^[2] has shown that quercetin's bioavailability in humans is relatively low, suggesting that dietary intake or supplementation needs careful consideration to achieve therapeutic effects.

Concerning safety, Harwood et al. (2007) provided a comprehensive review, arguing that quercetin is safe with no evidence of in vivo toxicity or carcinogenic properties.^[3] at consumption levels achievable through diet or supplementation.

What are the Health Benefits of Quercetin?

Anti-inflammatory and Immune Function

Quercetin's anti-inflammatory and immunomodulatory effects are well-documented. Davis, Murphy, & Carmichael (2009)^[4] and Konrad & Nieman (2015)^[5] discussed its potential to enhance physical performance and reduce illness by modulating immune function. These benefits are particularly notable in the context of exercise-induced stress, suggesting quercetin's role in supporting recovery and also reducing susceptibility to respiratory infections.

Quercetin has Antioxidant Properties

The antioxidant properties of quercetin, as reviewed by Young et al (1999)^[6], contributes to its protective effects against oxidative stress, potentially reducing the risk of chronic diseases, including cardiovascular diseases and cancer.

Anticancer Potential is Promising

Rauf et al. (2018).^[7] and Niedzwiecki et al. (2016).^[8] explored quercetin's anticancer efficacy, highlighting its ability to modulate various signaling pathways involved in cancer progression. The flavonoid's role in regulating the expression of genes related to cancer cell survival, growth, and metastasis underscores its potential as a complementary therapy in cancer treatment.

Cardiovascular Health

One study by Jia. (2019).^[9] demonstrated quercetin's protective effects against atherosclerosis by influencing the markers related to lipid metabolism and cholesterol regulation. These findings suggest quercetin could be a beneficial dietary component in preventing cardiovascular diseases.

Is quercetin good for dogs and people?

Based on available research, quercetin is an attractive ingredient for advanced dietary supplements providing wide-ranging health benefits, including anti-inflammatory, immuno-modulatory, antioxidant, and anti-cancer properties.

References

1. Moon, Y. J., Wang, L., DiCenzo, R., & Morris, M. E. (2008). Quercetin pharmacokinetics in humans. Clinical Trial Biopharm Drug Dispos, 29(4), 205-217. doi: 10.1002/bdd.605.
   
   

2. Graefe, E. U., Derendorf, H., & Veit, M. (1999). Pharmacokinetics and bioavailability of the flavonol quercetin.

3. Harwood, M., Danielewska-Nikiel, B., Borzelleca, J. F., Flamm, G. W., Williams, G. M., & Lines, T. C. (2007). A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food and Chemical Toxicology, 45(11), 2179-2205. doi:10.1016/j.fct.2007.05.015 
   
   

4. Davis, J. M., Murphy, E. A., & Carmichael, M. D. (2009). Effects of the dietary flavonoid quercetin upon performance and health.

5. Konrad, M., & Nieman, D. C. (Year). Evaluation of quercetin as a countermeasure to exercise-induced physiological stress. In Antioxidants in Sport Nutrition (Chapter 10). NIH NLM Logo.
   
   

6. Young, J. F., et al. (1999). Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status.
   
   

7.  Rauf, A., Imran, M., Khan, I. A., Rehman, M. U., Gilani, S. A., Mehmood, Z., & Mubarak, M. S. (2018). Anticancer potential of quercetin: A comprehensive review. Review Phytother Res, 32(11), 2109-2130. doi: 10.1002/ptr.6155.
   
   
8. Niedzwiecki, A., Roomi, M. W., Kalinovsky, T., & Rath, M. (2016). Anticancer Efficacy of Polyphenols and Their Combinations. Nutrients, 8(9), 552. doi: 10.3390/nu8090552.
   
   
9. Cao, H., Jia, Q., Shen, D., Yan, L., Chen, C., & Xing, S. (2019). Quercetin has a protective effect on atherosclerosis via enhancement of autophagy in ApoE−/− mice. Experimental and Therapeutic Medicine, 18(4), 2451–2458. doi: 10.3892/etm.2019.7851.
   
   

Unlocking Joint Health: The Benefits of MSM for Dogs

Looking for ways to reduce your dog’s joint pain and inflammation? For many years now, Methylsulfonylmethane (MSM) has been at the forefront of many joint and mobility supplements for dogs as a joint-protective agent to help prevent painful joints and injuries.

What is MSM?

It's a naturally occurring sulphur compound present in every living organism as an essential building block of collagen, cartilage and bones. MSM also supports the body’s natural detoxification process, helping to neutralize and remove toxins from cells and maintain optimal organ and tissue health.

Research has shown MSM is capable of strengthening the structural bonds of connective tissue and significantly improves joint health which makes it a key ingredient, especially for growing active and senior dogs.

So, how can your dog benefit from MSM’s anti-inflammatory and antioxidant properties? Are there any side effects? Can dogs get MSM from their food only, or do you need to give them a joint supplement?

I’ll focus on answering all of those questions and more in this blog, let’s dive in.

What is MSM methylsulfonylmethane?

You may find it interesting to learn that MSM is a source of bioavailable sulphur produced by oceanic plankton. When it dies, it's released into the atmosphere leading to the formation of dimethylsulphide (DMS), which then oxidizes to produce MSM.

When it rains, MSM is absorbed by plants which in turn enters the food chain.

Once MSM enters the system it is converted into two essential amino acids, methionine and cysteine, which help to reduce oxidative damage and support the production of proteins and enzymes.

The research behind MSM and its importance in your dog’s health

Sulphur is a cornerstone nutrient for countless biological functions in your dog’s body, including tissue repair as well as hair, skin and claw health as it helps to reduce inflammation and eliminate toxins.

Supplementing your dog's diet with MSM, a highly bioavailable form of sulphur, also provides the building blocks essential for healthy bones, joints, and ligaments.

In contrast to side-effect causing drug-based products, MSM can help protect or improve your dog’s mobility without the undesirable side-effects.

A summary of health benefits of MSM in dogs

While MSM has been mainly researched for its anti-inflammatory and analgesic properties, the benefits go beyond joint health, also showing promising results in the treatment of some types of cancers.

• A natural anti-inflammatory and joint pain relief

Research shows that MSM inhibits several inflammatory markers, reduces joint pain and regulates the immune response.^[1.1] MSM also lowers the release of inflammatory substances after heavy exercise^[2] ,  and speeds up the recovery.

• Cartilage and bone formation

A study on cell cultures and zebrafish has shown that MSM boosts cartilage growth and supports the early development of bone cells^[3] which makes MSM important in growing puppies and young dogs.

MSM also inhibits bone degradation which highlights the potential in preventing osteoporosis and promoting tissue regeneration.

Another study has found that MSM significantly increased jaw bone density by stimulating the production of osteoblasts (bone-forming cells)^[4] which again highlights its potential in the treatment of osteoporosis.

• Improves nutrient absorption and detoxification

MSM plays a dual role in cellular health by neutralizing and cleansing toxins from cells^[1.2]. It also enhances the absorption of nutrients by increasing the permeability of the cell membrane.

• Inhibits cancer cell growth

One study has shown that MSM may have the potential in fighting colon cancer by inducing apoptosis (programmed cell death)^[5] .

Another study confirmed that MSM reduced the growth of liver cancer cells^[6] and decreased the size and number of liver tumours.

How to ensure your dog is getting sufficient amounts of MSM

While leafy green vegetables, tomatoes, alfalfa sprouts, meat, and poultry are all foods that contain small amounts of MSM, it is practically impossible to provide your dog with therapeutic levels of MSM from diet alone.

Also, because food sourced MSM is unstable and sensitive to heat and processing, the most effective way to incorporate MSM into your dog’s diet is through high-quality canine supplements.

What is the best MSM supplement for your dog?

There are many dog joint supplements containing ingredients with anti-inflammatory, chondroprotective and antioxidant properties, including MSM, glucosamine, chondroitin, ginger and boswellia, however, there is a wide range of quality, purity, and potency of ingredients.

I realize many joint and mobility supplements are not based on clinical experience and research which is oftentimes why they may not work for your dog.

Ideally, when looking for the best MSM supplement for your dog, focus on a formula that not only contains MSM but has a wide range of mobility and joint supporting ingredients.

It is also important to choose products that are made with high-quality, sustainably sourced ingredients that are fermented for higher potency and bioavailability. This ensures your dog enjoys all the health benefits the ingredients have to offer faster and more effectively.

MSM for dogs-FAQ

• What does MSM do for dogs?

MSM can support your dog in many ways from reducing joint inflammation and pain, maintaining healthy ligaments and cartilage to protecting cells from toxins and oxidative damage.

• What foods are high in MSM for dogs?

Unfortunately, fruits, vegetables, and meats don’t provide adequate amounts of MSM, making it impossible to achieve significant changes by providing MSM containing foods alone. This is where a dog joint supplement that contains high quality MSM and other synergistic ingredients can make a difference. 

• How much MSM should I give my senior dog?

Similar to other herbs and supplements, the MSM dosage depends on your senior dog’s weight, overall health condition and the severity of joint issues. Follow the instructions on the joint supplement label to make sure your dog receives the right dose for their health needs.

• What should you not take with MSM?

MSM is considered very safe for dogs and people especially when it is blended with other fermented nutrients and herbs.  It is very unlikely that your dog would have negative side-effects caused by MSM, however, your goal should always be to reduce or ideally eliminate NSAID drugs.

• Is MSM better than glucosamine?  

MSM and glucosamine are often used in similar circumstances but have a different mode of action. While MSM has powerful anti-inflammatory and antioxidant properties that help maintain healthy joints, tendons and bones, glucosamine stimulates cartilage growth and helps reduce joint wear in dogs.

Both of these supplements work well in synergy to enhance joint function and mobility.

• Is MSM or chondroitin better for dogs?

Chondroitin helps keep your dog's cartilage healthy by retaining water, which slows natural joint degradation and improves cushioning to prevent wear and tear. MSM, on the other hand, aids in reducing joint pain and inflammation, making it easier for your dog to walk, jump, and run more comfortably. 

Choosing a joint supplement that combines not only MSM and chondroitin but also other natural ingredients that help maintain and repair connective tissues and address pain and inflammation is the best choice.

References

(1.1/1.2) Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017 Mar 16;9(3):290. doi: 10.3390/nu9030290.

(2) van der Merwe M, Bloomer RJ. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. doi: 10.1155/2016/7498359. Epub 2016 Oct 23.

(3) Dalle Carbonare L, Bertacco J, Marchetto G, Cheri S, Deiana M, Minoia A, Tiso N, Mottes M, Valenti MT. Methylsulfonylmethane enhances MSC chondrogenic commitment and promotes pre-osteoblasts formation. Stem Cell Res Ther. 2021 Jun 5;12(1):326. doi: 10.1186/s13287-021-02396-5.
 
(4) Aljohani H, Senbanjo LT, Al Qranei M, Stains JP, Chellaiah MA. Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice. Front Physiol. 2021 Oct 4;12:708905. doi: 10.3389/fphys.2021.708905.
 
(5) Karabay AZ, Koc A, Ozkan T, Hekmatshoar Y, Sunguroglu A, Aktan F, Buyukbingol Z. Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells. Int J Mol Sci. 2016 Jul 15;17(7):1123. doi: 10.3390/ijms17071123.
 
(6) Kim JH, Shin HJ, Ha HL, Park YH, Kwon TH, Jung MR, Moon HB, Cho ES, Son HY, Yu DY. Methylsulfonylmethane suppresses hepatic tumour development through the activation of apoptosis. World J Hepatol. 2014 Feb 27;6(2):98-106. doi: 10.4254/wjh.v6.i2.98.

The Science of Rutin's Power in Managing Osteoarthritis, Vascular and Chylothorax in Dogs

Rutin, a potent bioflavonoid found in a variety of plants, fruits, and vegetables, is gaining recognition for its extensive health benefits in both human and veterinary medicine. This comprehensive exploration delves into the multifaceted effects of Rutin on health, its critical role in integrated medicine, and its potential benefits for canine companions, in managing conditions such like arthritis, inflammatory conditions and chylothorax.

The Broad-Spectrum Benefits of Rutin

Rutin's health benefits are wide-ranging, thanks to its antioxidant, anti-inflammatory, and also plays a pivotal role in promoting vascular health, enhancing the integrity of blood vessels, and supporting the lymphatic system's function.

Rutin is instrumental in improving blood circulation, cholesterol levels and preventing blood clots, varicose veins and hemorrhoids.^[1]

Osteoarthritis Management

Rutin, when combined with enzymes, has shown promise as an effective alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) for managing osteoarthritis symptoms.^[2] This combination offers symptom relief without the side effects commonly associated with NSAIDs, making it a potentially safer option for long-term management of osteoarthritis.^[3]

Benefits of Rutin in Canine Health

The benefits of Rutin extend to our canine friends, where it supports pet health through its vascular and anti-inflammatory effects. "Rutin for dogs" and "Canine Rutin" have become popular terms among pet owners seeking natural remedies to support their pets' health.

• Joint Health in Dogs

Aging dogs, particularly medium and larger breeds and older animals, often suffer from joint issues like arthritis. Based on research, rutin’s anti-inflammatory properties appear to reduce joint pain and inflammation, enhancing mobility and comfort.

• Rutin and chylothorax

Rutin exemplifies the integration of natural supplements with traditional medical treatments, offering a holistic approach to health care. This is particularly evident in its use for managing chylothorax in dogs, a condition marked by the accumulation of lymphatic fluid in the chest cavity.

In such cases, the dose of rutin used in dogs and cats is 50mg/kg every 8 hrs (approximately 20mg/lb).

• Aging-Related Metabolic Dysfunction

Rutin has been shown to improve metabolic parameters in aged rats, indicating its potential in combating aging-related metabolic diseases. This effect underscores Rutin's role in promoting health and wellness across the lifespan, including its application in anti-aging strategies.^[4]

The Enhanced Benefits of Fermented Rutin

Fermentation, a process that increases the nutritional value and bioavailability of supplements, can amplify Rutin's benefits. Fermented Rutin is more easily absorbed by the body and it is an important ingredient when it comes to searching for the best Rutin supplement for dogs. 

As you can see there are scientifically based benefits or Rutin which makes it an interesting and useful nutrient when it comes to managing osteoarthritis, improving cholesterol metabolism, offering anti-inflammatory benefits, or combating aging-related metabolic dysfunction. 

Click here for more details on a Rutin containing fermented supplement

References

1. Shaĭkemeleva, U. S. (1983). Effect of rutin on the cholesterol content of the lymph, blood and tissues of the dog. Biulleten' Eksperimental'noi Biologii i Meditsiny, 95(3), 35-7. PMID: 6830981.

2. Henrotin, Y. E., Michlmayr, C., Rau, S. M., Quirke, A. M., Bigoni, M., & Ueberall, M. A. (2022). Combination of Enzymes and Rutin to Manage Osteoarthritis Symptoms: Lessons from a Narrative Review of the Literature. Rheumatology and Therapy, 9(5), 1305–1327. .

3. Sun, C.-L., Wei, J., & Bi, L.-Q. (2017). Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB. Pharmacology, 100(1-2), 40–49. 

4. Li, T., Chen, S., Feng, T., Dong, J., Li, Y., & Li, H. (2016). Rutin protects against aging-related metabolic dysfunction. Food & Function, 7(2), 1147-1154. https://doi.org/10.1039/c5fo01036e.